BRI2 function in the CNS and the impact of pathogenic mutations
About This Grant
This study aims to investigate the role of ITM2B/BRI2 in the pathogenesis of dementias such as FBD and FDD, which share similarities with AD. It explores the impact of BRI2 on synaptic plasticity, learning and memory, neuroinflammation, and cell type-specific changes in microglia and neurons. The investigation utilizes animal models, including mice lacking Bri2 expression in specific cell types (excitatory neurons, inhibitory neurons or microglia), FDD- KI and FBD-KI rodents, as well as isogenic human iPSC-derived cells with KO and mutant FDD or FBD ITM2B alleles. The study also involves analyzing brain specimens from FDD and FBD patients using single-nuclei RNA sequencing and spatial gene expression analysis. The research aims to develop interventions targeting the interaction of BRI2 with two key proteins associated with AD, namely APP and TREM2. These interventions aim to correct BRI2 dysfunctions that contribute to dementia. Specifically, the efficacy of BRI2-derived peptides in modulating APP and TREM2 processing will be evaluated. Overall, this study seeks to provide insights into the multifaceted role of BRI2 and its potential as a therapeutic target for AD and ADRD.
Grant Summary
BRI2 function in the CNS and the impact of pathogenic mutations is a NIA - National Institute on Aging grant providing up to $657K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $657K
2031-03-31
- 1Confirm your organization is eligible for BRI2 function in the CNS and the impact of pathogenic mutations from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIA - National Institute on Aging before the deadline.
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BRI2 function in the CNS and the impact of pathogenic mutations: Frequently Asked Questions
Who is eligible for the BRI2 function in the CNS and the impact of pathogenic mutations?
BRI2 function in the CNS and the impact of pathogenic mutations is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the BRI2 function in the CNS and the impact of pathogenic mutations provide?
BRI2 function in the CNS and the impact of pathogenic mutations provides up to $657K per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the BRI2 function in the CNS and the impact of pathogenic mutations deadline?
Applications for BRI2 function in the CNS and the impact of pathogenic mutations are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the BRI2 function in the CNS and the impact of pathogenic mutations?
To apply for BRI2 function in the CNS and the impact of pathogenic mutations, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.