Epigenetic regulation of heart function in health and aging
About This Grant
Project Summary/Abstract In humans, the heart function declines due to aging. The prevalence of heart disease increases with age. Aging, even in apparently healthy individuals without overt cardiovascular disease, is associated with damaged heart structure and comprised cardiac function. Aging is an important risk factor for heart diseases. KDM6A is a recently-discovered histone demethylase. Mutation of this gene causes severe defective embryogenesis. The objective of the proposed research is to investigate if KDM6A plays a role in the regulation of normal heart function and further investigate if KDM6A deficiency is involved in the epigenetic determinants of responses to aging-related heart injury. This objective will be achieved by pursuing two coherent specific aims using a combination of several novel approaches. The proposed work is innovative and significant because it utilizes state-of-the-art approaches to address the aging-related heart damage which affects a large population but remains poorly understood. The results will reveal novel molecular mechanisms that mediate the pathogenesis of aging-associated heart failure and remodeling. Completion of this project may provide new insights into preventive and therapeutic strategies for heart aging.
Grant Summary
Epigenetic regulation of heart function in health and aging is a NIA - National Institute on Aging grant providing up to $624K for university, nonprofit, healthcare org. Applications are due 2031-04-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $624K
2031-04-30
- 1Confirm your organization is eligible for Epigenetic regulation of heart function in health and aging from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIA - National Institute on Aging before the deadline.
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Epigenetic regulation of heart function in health and aging: Frequently Asked Questions
Who is eligible for the Epigenetic regulation of heart function in health and aging?
Epigenetic regulation of heart function in health and aging is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Epigenetic regulation of heart function in health and aging provide?
Epigenetic regulation of heart function in health and aging provides up to $624K per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Epigenetic regulation of heart function in health and aging deadline?
Applications for Epigenetic regulation of heart function in health and aging are due 2031-04-30 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Epigenetic regulation of heart function in health and aging?
To apply for Epigenetic regulation of heart function in health and aging, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.