Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse
NIA - National Institute on Aging
About This Grant
PROJECT SUMMARY Pelvic organ prolapse (POP) is an age-related disorder that affects up to 50% of women impacting quality of life and resulting in exorbitant healthcare costs. On a cellular level, the process of aging is termed cellular senescence and it has been associated with degenerative and age-related diseases. Despite current studies suggesting a link between POP and cellular senescence there is a lack of understanding of how senescence- associated changes contribute to the development of prolapse. In this application we will test the hypothesis that induction of cell senescence culminates in POP during aging. To accomplish this, we will use state-of-the art methodologies (single-cell and single-nuclei RNA sequencing; biomechanical phenotyping considering both contractile and non-contractile properties) to reveal new facets of cell senescence signaling pathways in the vagina with age and known development of prolapse. We will employ a translational approach that combines both human research and animal models, which will allow for longitudinal follow-up that is not feasible in humans. Our specific aims are to (1) identify the differential gene expression and extracellular matrix regulation of age- related POP using an animal model, (2) determine if vaginal contractile potential and biomechanical stability are rescued in a novel mouse model of prolapse and cellular senescence, and (3) link extracellular matrix composition with cell senescence in vaginal stromal tissues from women with and without prolapse. The research proposed here will help define the mechanism of cell senescence in initiating the path of loss of pelvic organ support during aging. Identification of cellular pathways and unique cell populations associated with the development of prolapse can result in the design of interventional strategies that can prevent or slow the progression of cell senescence and in turn prevent development of POP. Successful execution of the aims of the proposed study will transform pelvic floor medicine and inform other aspects of the biology of aging.
Grant Summary
Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse is a NIA - National Institute on Aging grant providing up to $719K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $719K
2031-01-31
- 1Confirm your organization is eligible for Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIA - National Institute on Aging before the deadline.
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Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse: Frequently Asked Questions
Who is eligible for the Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse?
Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse provide?
Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse provides up to $719K per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse deadline?
Applications for Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse?
To apply for Impact of Cellular Senescence on the Development of Pelvic Organ Prolapse, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.