Lympnoids tissue senescence and multimodal imaging using REDCAT
NIA - National Institute on Aging
About This Grant
SUMMARY Cellular senescence, a hallmark of aging, is an irreversible state of cell cycle arrest in otherwise proliferative cells. Senescence in immune organs is particularly significant in aging and disease, as immune cells circulate throughout the body and regulate the physiological functions of all major organs. Metabolic alterations play a crucial role in immunosenescence and are recognized as key mechanisms driving abnormal immune homeostasis. To better understand the distinct role of senescent cell metabolism – for example, in thymic aging and immune function – there is a pressing need for novel methods to map senescent cells and cell-type-specific metabolism within complex tissues to assess their impact on the local environment. Given the critical role of immune senescence in systemic, organism-level aging, we hypothesize that: (i) thymic epithelial cell (TEC) senescence plays a key role in driving thymic aging. (ii) abnormal metabolic dynamics, including lipid metabolism and accumulated adipocytes in aged thymi, contribute to reduced T-cell diversity, (iii) senescence and aging in the thymus lead to systemic immune function decline. To address these hypotheses, we propose to develop and deploy an integrated platform, Raman Enhanced Determination of Cell Atlas and Typing (REDCAT), for mapping single-cell metabolic activity in complex tissues and decoding the underlying transcriptional and epigenomic mechanisms. It will be applied to the study of thymic aging in wild-type, lineage-tracked, and FGF21 mouse models. Specifically, we will (1) develop REDCAT for single-cell resolution profiling of cellular senescence in complex lymphoid tissues, (2) examine senescence-associated transcriptomic mechanisms via integrating DBiT- Based spatial transcriptome sequencing, and (3) investigating dynamic phenotypic and metabolomic heterogeneity of senescent cells in thymic aging and the impact on tissue microenvironments and systemic immune function. The proposed techniques can be widely adopted by the cellular senescence and aging research community. This work will also generate a valuable data resource to unveil insights in thymic aging to advance fundamental understanding of immuno-senescence and propel translational developments in anti- senescence interventions aimed at improving immune function and overall healthspan.
Grant Summary
Lympnoids tissue senescence and multimodal imaging using REDCAT is a NIA - National Institute on Aging grant providing up to $701K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $701K
2031-01-31
- 1Confirm your organization is eligible for Lympnoids tissue senescence and multimodal imaging using REDCAT from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIA - National Institute on Aging before the deadline.
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Lympnoids tissue senescence and multimodal imaging using REDCAT: Frequently Asked Questions
Who is eligible for the Lympnoids tissue senescence and multimodal imaging using REDCAT?
Lympnoids tissue senescence and multimodal imaging using REDCAT is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Lympnoids tissue senescence and multimodal imaging using REDCAT provide?
Lympnoids tissue senescence and multimodal imaging using REDCAT provides up to $701K per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Lympnoids tissue senescence and multimodal imaging using REDCAT deadline?
Applications for Lympnoids tissue senescence and multimodal imaging using REDCAT are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Lympnoids tissue senescence and multimodal imaging using REDCAT?
To apply for Lympnoids tissue senescence and multimodal imaging using REDCAT, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.