A multi-tissue temporal framework for Th2 responses
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
The central objective of this P01 is to define a unifying framework for how Type 2 immune responses are initiated, maintained, and recalled across barrier tissues. Type 2 immunity is critical for defense against helminths and drives pathology in chronic allergic diseases such as asthma, eczema, and food allergy. Despite its clinical importance, how these responses are coordinated across diverse tissue environments remains poorly understood. Each barrier tissue—gut, skin, and lung—has unique structural and sensory elements that shape immunity, prompting the question: are there conserved principles or tissue-specific programs driving Type 2 inflammation? This program integrates four interdependent projects, each addressing a distinct tissue context and complementary biological question: Project 1 (P1, Small Intestine): Defines a neuro-epithelial-immune circuit involving tuft cells and Neuromedin U neurons and tests how this circuit regulates ILC2s and Th2s during helminth infections; Project 2 (P2, Skin): Reveals hair follicles as neuro-immune hubs shaping allergic sensitization and IgE production, with distinct roles in different skin types; Project 3 (P3, Large intestine): Explores how Notch-programmed basophils form inflammatory niches that support Th2 tissue-resident cells and memory during whipworm infection in the large intestine; and Project 4 (P4, Lung): Identifies spatially distinct Th2 tissue-resident memory populations in novel immune hubs that we hypothesize regulate their maintenance and the exacerbation of allergic lung inflammation. Together, these projects address three program-wide themes: initiation and priming of Th2 responses, neuroimmune regulation, and tissue-resident memory and recall. Harmonized methods and shared resources enable rigorous cross-tissue comparisons and mechanistic insight. Synergy and unique expertise across projects is the program’s core strength. Discoveries in one tissue rapidly inform hypotheses in others, creating an iterative feedback loop that amplifies innovation and discovery. The centralized cores; Administration, Microscopy and Mouse, provide shared infrastructure for advanced imaging, genetically engineered mouse models (>50 alleles), and data integration, enhancing efficiency and rigor. This level of coordination and resource sharing is uniquely enabled by the P01 mechanism and could not be achieved through separate grants. Our combined approach reveals conserved immune hubs and tissue-specific adaptations that redefine how Type 2 immunity is orchestrated across organs and will reveal novel targets to enhance or suppress this response. By integrating mechanistic studies with translational relevance—validated in human tissues—this P01 establishes foundational principles for manipulating Type 2 inflammation in infectious and allergic diseases, delivering transformative insights only possible through this synergistic program.
Grant Summary
A multi-tissue temporal framework for Th2 responses is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $2.7M for university, nonprofit, healthcare org. Applications are due 2031-05-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $2.7M
2031-05-31
- 1Confirm your organization is eligible for A multi-tissue temporal framework for Th2 responses from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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A multi-tissue temporal framework for Th2 responses: Frequently Asked Questions
Who is eligible for the A multi-tissue temporal framework for Th2 responses?
A multi-tissue temporal framework for Th2 responses is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A multi-tissue temporal framework for Th2 responses provide?
A multi-tissue temporal framework for Th2 responses provides up to $2.7M per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A multi-tissue temporal framework for Th2 responses deadline?
Applications for A multi-tissue temporal framework for Th2 responses are due 2031-05-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A multi-tissue temporal framework for Th2 responses?
To apply for A multi-tissue temporal framework for Th2 responses, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.