Linking physiology, computation and circuitry in the primate visual cortex
NEI - National Eye Institute
About This Grant
PROJECT SUMMARY The aim of this proposal is to determine the biological underpinnings of canonical computations in the brain. The focus will be on how these computations manifest in primate visual system, which is the classical system for identifying such transformations of information. Canonical computations are fundamental processing patterns that underlie a wide range of neural functions, impacting perception and cognition across hierarchical brain networks. However, there are large families of possible biological circuits that could implement these computations and, likewise, vastly different computations can be implemented with the same or very similar neural circuitry. What is needed to advance our understanding of these computations in the brain is a way to bridge the gap between physiology, computation and circuitry in a tractable, generalizable model living system. Marmoset early visual areas V1 and V2 are the perfect testbed to develop models of cortico-cortical computations and circuits, some of which will generalize to the rest of the visual system and to hierarchical transformations of information throughout the primate neocortex. An exhaustive dataset of simultaneous V1 and V2 neural responses with high density electrophysiology and calcium imaging will be collected in combination with perturbations using virally mediated opto- and chemo-genetic tools to test models of a canonical interareal circuit. In contrast to the mouse model, where these tools have largely been developed and implemented, the marmoset has prototypical primate neural circuits closely related to our own, but in a simpler and more accessible brain than that of larger primates. The training aims of this proposal support the development of the analysis and genetic tools that are required to understand the transformation of information between V1 and V2. These support an independent research phase, to dissect the circuits involved in interareal transformations and extend the analysis to additional stages of the visual hierarchy. The overall goal of the project is to understand the transformation of information between areas in the visual system ultimately to arrive at a canonical model for cortico-cortical computation and circuitry across the brain.
Grant Summary
Linking physiology, computation and circuitry in the primate visual cortex is a NEI - National Eye Institute grant providing up to $132K for university, nonprofit, healthcare org. Applications are due 2028-04-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $132K
2028-04-30
- 1Confirm your organization is eligible for Linking physiology, computation and circuitry in the primate visual cortex from NEI - National Eye Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NEI - National Eye Institute before the deadline.
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Linking physiology, computation and circuitry in the primate visual cortex: Frequently Asked Questions
Who is eligible for the Linking physiology, computation and circuitry in the primate visual cortex?
Linking physiology, computation and circuitry in the primate visual cortex is offered by NEI - National Eye Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Linking physiology, computation and circuitry in the primate visual cortex provide?
Linking physiology, computation and circuitry in the primate visual cortex provides up to $132K per award from NEI - National Eye Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Linking physiology, computation and circuitry in the primate visual cortex deadline?
Applications for Linking physiology, computation and circuitry in the primate visual cortex are due 2028-04-30 (open). Because deadlines can change, verify the date with the funder, NEI - National Eye Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Linking physiology, computation and circuitry in the primate visual cortex?
To apply for Linking physiology, computation and circuitry in the primate visual cortex, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NEI - National Eye Institute.