The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation
NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases
About This Grant
PROJECT SUMMARY Rotator cuff tendinopathy is a prevalent chronic disease that is painful, debilitating, and reduces the quality of life. Physical therapy (PT) is an effective first-line treatment, but the non-response rate to PT is still high. Long- term recovery is further limited, and the reason for pain recurrence is poorly explained. It is possible that the in- clinic gains of PT fail to translate to good real-world mechanics and are overwhelmed by the pathomechanical shoulder movements in activities of daily living. Clinical and basic science both suggest shoulder overuse and motion-driven pathomechanics are causal factors of rotator cuff pathology. These biomechanical mechanisms are unconfirmed in patients partly due to the complex interplays among pathology, mechanics, and treatment, in addition to a paucity of methods to quantify the highly variable real-world motion and in-vivo tendon loading. My overall goal is to discover how real-world shoulder biomechanics interact with the clinical outcomes of PT in rotator cuff tendinopathy. This research progresses from a cross-sectional [K99] to a longitudinal cohort study [R00]. My cross-sectional Aim 1 [K99] will use 1) wearable sensors to track 7-day bilateral shoulder cumulative motion in daily living; 2) motion analysis and musculosketeal models to identify motion-driven pathomechanics specific to daily living functional tasks; and 3) machine learning to combine sensor-detected activities with motion-driven biomechanics to quantify real-world cumulative rotator cuff tendon loading. My mentored K99 will validate research tools and define how patient shoulder motion and tendon loading deviate from normal status. The longitudinal Aim 2 [R00] will link the real-world biomechanics established in Aim 1 with changes in clinical outcomes, including pain, shoulder function, and tendon structure, through a 3-month PT protocol followed by the first 6 months after PT completion. These Aims will clarify the mechanical mechanisms on how real-world shoulder motion and loading alter the course of PT clinical outcomes in rotator cuff tendinopathy. Findings will inform data-driven continuous rehabilitation paradigms that monitor and modify daily living activities to maintain long-term shoulder health. This research will also serve as the foundation of Dr. Ke Song's career development plan to acquire 2 years of mentored training [K99] and prepare for transition into independence [R00]. Through the guidance of his experienced and interdisciplinary mentoring team, Dr. Song will perform hands-on training with field-leading experts in shoulder biomechanics, physical therapy, orthopaedics, wearable sensors, data science, and biostatistics to maximize the impact of his proposed research. Dr. Song will also learn from formal courses and professional training activities to ensure his career progress, develop clinical research proficiency, improve grant writing, mentoring, and leadership skills, and secure an independent tenure-track faculty position at a clinical research-intensive institution. The scientific training, professional development, and research plans will guide Dr. Song through a pathway to independent research in translational musculoskeletal biomechanics that help patients with rotator cuff tendinopathy and related shoulder diseases improve long-term outcomes.
Grant Summary
The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation is a NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases grant providing up to $129K for university, nonprofit, healthcare org. Applications are due 2028-04-30 (open). Check eligibility and apply with FindGrants.
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Up to $129K
2028-04-30
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The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation: Frequently Asked Questions
Who is eligible for the The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation?
The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation is offered by NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation provide?
The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation provides up to $129K per award from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation deadline?
Applications for The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation are due 2028-04-30 (open). Because deadlines can change, verify the date with the funder, NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation?
To apply for The roles of real-world shoulder biomechanics in rotator cuff tendinopathy rehabilitation, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases.