A Prospective, Longitudinal Investigation of Physical Activity and Bone Health among Female Adolescents Recovering from Restrictive Eating Disorders

About This Grant

PROJECT SUMMARY/ABSTRACT Restrictive eating disorders (EDs) most commonly affect female adolescents and can lead to low bone mineral density (BMD) and impaired bone microarchitecture. Peak bone accrual occurs during adolescence, and the presence of a restrictive ED at this time can increase the risk of osteoporosis into adulthood. Weight-bearing physical activity can promote bone accrual, but the bone health benefits may be reduced with an ED. Physical activity participation is often restricted during ED treatment due to concerns for compulsive exercise (i.e. rigid and highly-driven exercise behaviors) and interference with weight restoration. Data is lacking regarding if, when, and how patients return to physical activity and the associations with compulsive exercise and eating disorder behaviors during ED recovery. Additionally, the changes in BMD and bone microarchitecture, and the impact of weight-bearing physical activity on bone health in female adolescents as they recover from a restrictive ED are unknown. Addressing these knowledge gaps is essential to inform the clinical approach to physical activity integration and optimization of bone health during ED recovery among female adolescents. Dr. Aubrey Armento will conduct a prospective longitudinal clinical study of female adolescents admitted to the Children’s Hospital Colorado Eating Disorder Program (CHCO-EDP) over 1 year of treatment/recovery, compared to a healthy, physically active control group. The specific aims include: 1) examine physical activity participation (as measured by a wearable activity monitor) and its association with compulsive exercise and eating disorder behaviors, and 2) determine changes in BMD and bone microarchitecture and estimated strength (as measured by high resolution peripheral quantitative computed tomography; HR-pQCT) and the impact of weight-bearing physical activity on these bone outcomes. The findings of this study could shift current clinical paradigms to improve the health and well-being of female adolescents with restrictive EDs. In addition to obtaining valuable experiential training through completion of the proposed study, Dr. Armento will complete a career development plan designed to develop proficiency and expertise in conducting longitudinal clinical studies, analyzing and interpreting HR-pQCT data, and physical activity monitoring using wearable technology. During her time as a K12 scholar, Dr. Armento has established a productive working relationship with the CHCO-EDP, demonstrated feasibility of recruiting this study population, and collected pilot data. The additional time offered through the K23 award is essential to address her persisting training gaps and collect foundational data for a future R01 proposal. With ongoing support from her expert multidisciplinary team and the robust research and education infrastructure offered through the University of Colorado, Dr. Armento is well-equipped to develop into a successful independent investigator of the bone health consequences of EDs in female adolescents and the potential therapeutic benefits of physical activity.