Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
ABSTRACT Human immunodeficiency virus-1 (HIV-1) remains incurable except in rare cases. The ultimate barrier to sustained remission without continuous antiretroviral therapy (ART) is the HIV-1 reservoir, which remains under-characterized, particularly across individuals who differ by age, sex, and ART history. This submission is for a Mentored Patient-Oriented Research Career Development Award (K23) entitled “Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay”. I am an Assistant Professor at the University of Pittsburgh specializing in HIV medicine and general infectious diseases. I developed this proposal to leverage multi-dimensional platforms to investigate drivers of change in the HIV-1 reservoir over a decade of suppressive ART, with the ultimate goal of identifying new approaches to eliminating the HIV-1 reservoir. It seeks to examine the longitudinal decay patterns of intact proviruses, a robust marker for the HIV-1 reservoir. I am particularly interested in the interaction between age, sex, hormone levels, HIV-1 immune responses, and HIV-1 reservoir dynamics. My preliminary study, supported by the Rustbelt Center for AIDS Research (CFAR) pilot funding, suggests there are distinct patterns of HIV-1 provirus decay and immunological correlates in females compared to males with HIV. Further studies and training are needed to take these preliminary findings to the next level and systematically dissect the chronological, virological, immunological, and hormonal influences of HIV-1 reservoir dynamics. The findings from this proposed study would help identify therapeutic targets for HIV-1 reservoir clearance. To gain the skills necessary to achieve my career goal of becoming an independent translational physician-scientist, I propose this career development plan that includes mentoring from Drs. John Mellors, Charles Rinaldo, and Mark Cameron (primary mentors), along with Drs. Bernard Macatangay, Sharon Riddler, and Nicolas Sluis-Cremer (advisory team). This team represents research leaders across HIV-1 virology, immunology, single-cell sequencing, and systems biology. This project will utilize de-identified data and samples obtained from the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study Combined Cohort (MWCCS), a four-decade longitudinal multicenter cohort studying individuals with or at high risk for HIV- 1 infection. Dr. Charles Rinaldo, one of the primary mentors for this project, is also one of the founding scientists of MWCCS. The proposed work will be conducted at the Division of Infectious Diseases at the University of Pittsburgh, Pittsburgh, PA and Case Western Reserve University Comprehensive Cancer Center, Cleveland, OH. Guided by highly supportive mentors who are the top experts in their fields, with unwavering support from my department, I am confident that I will acquire the skillset required to perform cutting-edge translational studies on the HIV-1 reservoir that will lead to innovative approaches to achieve HIV-1 remission. 1
Grant Summary
Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $171K for university, nonprofit, healthcare org. Applications are due 2031-06-30 (open). Check eligibility and apply with FindGrants.
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Up to $171K
2031-06-30
- 1Confirm your organization is eligible for Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay: Frequently Asked Questions
Who is eligible for the Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay?
Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay provide?
Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay provides up to $171K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay deadline?
Applications for Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay are due 2031-06-30 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay?
To apply for Sex Differences in HIV-1 Reservoir- a Multi-omic Approach to Identify Mechanisms of Reservoir Decay, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.