Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis
About This Grant
PROJECT SUMMARY Candidate: I aim to build an independent career as an R01-funded physician scientist investigating the neurobiology of idiopathic pulmonary fibrosis (IPF). Under the guidance of my mentor and advisors, I have received training in this area using experimental models. I now propose career development activities to extend this training and develop a research program that is distinct from that of my mentor. Mentors, Career Development, and Institutional Commitment: My mentor, Dr. Herzog, is an international leader in IPF neurobiology and has an impressive record of scientific contributions and mentoring. Advisors are Dr. Dixit, adrenergic innervation and tissue remodeling expert; Dr. Sinha, noradrenaline and α1-adrenoreceptor authority; Dr. Gonzalez, humanized model inventor; and Dr. Sauler, lung genomics specialist. My career development plan includes research training, coursework, and physician scientist identity formation. Yale School of Medicine’s biomedical research enterprise and mentorship culture will foster my success. My department Chair (Dr. Desir) affirms that 75% of my time will be dedicated to career development, and he and my Section Chief (Dr. Kaminski) have confirmed their commitment. Research Project: IPF is a fatal condition of chronic lung scarring due to (myo)fibroblast-driven tissue remodeling. Dr. Herzog established that adrenergic nerve derived noradrenaline (NA) drives experimentally induced lung fibrosis via α1-adrenoreceptors (α1-ARs/ADRA1s), that IPF lungs are enriched for NA and ADRA1D+ (myo)fibroblasts, and that IPF patients prescribed α1-AR antagonists for non- pulmonary indications experience improved clinical outcomes. I reported that adrenergic nerve derived NA and ADRA1D sustain (myo)fibroblast activation and fibrosis in TGFβ1-dependent experimental models and, potentially, in IPF lungs. This discovery frames NA and ADRA1D as therapeutic targets but molecular mechanisms and human impact are undefined. My proposal forms the educational framework for my career development and tests the hypothesis that interactions between adrenergic nerve derived NA and ADRA1D sustain TGFβ1-induced (myo)fibroblast accumulation and fibrosis in IPF patient samples and in human relevant modeling systems. Using primary human samples, nerve-fibroblast co-culture, advanced lung models, and single-cell and spatial transcriptomics I will: 1) determine the significance of adrenergic nerves, NA, and ADRA1D+ (myo)fibroblasts in IPF lungs; 2) decode the mechanism through which NA sustains TGFβ1-induced ADRA1D+ (myo)fibroblast activation and its associated fibrogenic functions ex vivo; and 3) define the TGFβ1- dependent mechanism through which adrenergic nerve derived NA sustains ADRA1D+ (myo)fibroblast activation and its associated lung fibrosis in vivo. These studies will generate clinically relevant knowledge regarding adrenergic nerves, NA, and ADRA1D+ (myo)fibroblasts in pulmonary fibrosis and form my path to independence as a physician scientist focused on IPF neurobiology.
Grant Summary
Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis is a NHLBI - National Heart Lung and Blood Institute grant providing up to $166K for university, nonprofit, healthcare org. Applications are due 2031-06-30 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $166K
2031-06-30
- 1Confirm your organization is eligible for Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis from NHLBI - National Heart Lung and Blood Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NHLBI - National Heart Lung and Blood Institute before the deadline.
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Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis: Frequently Asked Questions
Who is eligible for the Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis?
Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis is offered by NHLBI - National Heart Lung and Blood Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis provide?
Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis provides up to $166K per award from NHLBI - National Heart Lung and Blood Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis deadline?
Applications for Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis are due 2031-06-30 (open). Because deadlines can change, verify the date with the funder, NHLBI - National Heart Lung and Blood Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis?
To apply for Adrenergic Nerves, Noradrenaline, and Myofibroblasts in Idiopathic Pulmonary Fibrosis, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHLBI - National Heart Lung and Blood Institute.