Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis
NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
About This Grant
PROJECT SUMMARY/ABSTRACT Stillbirth (SB) and Fetal Structural Anomalies (FSA) are serious developmental conditions impacting an estimated 1 in 175 and 1 in 33 pregnancies in the United States, respectively. These outcomes result in significant long-term disability and impose a substantial socioeconomic burden. While genetic research has provided insights into contributing factors, a comprehensive understanding of the phenotypic and genotypic contributors and their relationship to postnatal developmental delay remains limited. Integrating large-scale genomic and phenotypic data, along with implementing a collaborative framework for data federation and sharing, holds promise for advancing precision medicine approaches in perinatal diagnostics. The following proposal outlines a 5-year career training plan that will prepare me to be an independent physician-scientist and a leader in the field of perinatal precision diagnosis. The central aim of this proposal is to investigate the genetic and phenotypic overlap between SB, FSA and developmental delay by leveraging robust, large-scale datasets. The specific objectives are to: (1) identify pathogenic and candidate variants; (2) perform a comprehensive analysis of phenotypes and their correlation with genotypes across prenatal indications and; (3) standardize and harmonize genotype and phenotype data for broader community use all while incorporating advanced statistical methodologies and phenotype-driven variant prioritization. These aims will uncover key biological pathways and genetic risk factors shared between indications and will represent a fundamental advancement towards understanding the genetic etiologies of prenatal presentations of disease. The project will be led by Dr. Michael Duyzend, a physician-scientist with expertise in medical genetics, variant interpretation, cohort-building, and the genomics of the developmental continuum. He has a minimum of 80% protected time from the Boston Children’s Hospital Division of Genetics and Genomics to accomplish these aims under the guidance of Dr. Michael Talkowski at the Center for Genomic Medicine at Massachusetts General Hospital and the Broad Institute. He has assembled a distinguished team of co-mentors and advisors with complimentary expertise who will further support the research and career development components of his training program. Dr. Duyzend details a comprehensive training plan that takes advantage of his unique cross- institutional collaboration that includes mentored research, targeted coursework, national and international conference participation, preparation of manuscripts, and pursuit of additional independent funding, ultimately culminating in an R01 submission. Dr. Duyzend has the commitment of all involved institutions to accomplish these goals and transition to an independent physician-scientist position by the end of the award.
Grant Summary
Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis is a NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development grant providing up to $167K for university, nonprofit, healthcare org. Applications are due 2031-06-30 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $167K
2031-06-30
- 1Confirm your organization is eligible for Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development before the deadline.
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Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis: Frequently Asked Questions
Who is eligible for the Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis?
Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis is offered by NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis provide?
Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis provides up to $167K per award from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis deadline?
Applications for Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis are due 2031-06-30 (open). Because deadlines can change, verify the date with the funder, NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis?
To apply for Dissecting the Genetic and Phenotypic Architecture of Stillbirth and Fetal Structural Anomalies to Improve Prenatal Diagnosis, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development.