Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta
NIEHS - National Institute of Environmental Health Sciences
About This Grant
Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta Project Summary/Abstract: Micro and nanoplastics (MNPs), are increasingly pervasive in our environment. Microplastics are typically defined as plastic particles smaller than 5 millimeters (5mm), while nanoplastics are even smaller, measuring less than 1 micrometer (1 µm) Originating from the degradation of plastic materials entering our landfills, oceans, and water sources, micro and nanoplastics pose significant concerns for human health. Recent research has expanded its focus on investigating the interactions between microplastics and human placenta, with the understanding of the pivotal role that the placenta has in fetal health and development. This study introduces a groundbreaking perspective aimed at addressing the substantial knowledge gap present about how microplastics translocate into placental tissue and the critical role that chylomicrons may have in facilitating this process. The working hypothesis is that chylomicron-mediated microplastic uptake compromises placental barrier function, leading to the accumulation of microplastics within the placenta and ultimately alters barrier function and cellular response. Utilizing state-of-the-art quantitative methods in previous studies, we have established that the average human placenta at full term contains 130ug/g of total plastics, predominantly comprising polyethylene (53%), polyvinylchloride (10%), and nylon (8.7%). The combination of the prior and this proposed study promises to significantly advance our understanding of the intricate interactions of microplastics, placental function, and fetal development. By gaining a broader understanding of the crucial role of chylomicrons in facilitating microplastic uptake and the consequences, thereof, this research will guide how potential mitigation of microplastic contamination may play a role on maternal and fetal health outcomes.
Grant Summary
Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta is a NIEHS - National Institute of Environmental Health Sciences grant providing up to $168K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $168K
2031-03-31
- 1Confirm your organization is eligible for Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta from NIEHS - National Institute of Environmental Health Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIEHS - National Institute of Environmental Health Sciences before the deadline.
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Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta: Frequently Asked Questions
Who is eligible for the Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta?
Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta is offered by NIEHS - National Institute of Environmental Health Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta provide?
Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta provides up to $168K per award from NIEHS - National Institute of Environmental Health Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta deadline?
Applications for Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NIEHS - National Institute of Environmental Health Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta?
To apply for Lipoprotein-mediated Nanoplastic Uptake and Transport Across the Placenta, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIEHS - National Institute of Environmental Health Sciences.