Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
PROJECT ABSTRACT The thick ascending limb (TAL) of the nephron plays a central role in sodium and potassium homeostasis, but its ability to adapt to dietary potassium stress remains poorly defined. Preliminary data indicate that the inwardly rectifying potassium channel Kir4.1 is selectively expressed in distinct TAL cell populations and may function as a basolateral potassium sensor. This career development proposal tests the hypothesis that Kir4.1 regulates TAL transport and drives structural and transcriptional remodeling in response to changes in extracellular potassium concentration that accompany extremes of dietary potassium intake. To test this hypothesis, the research integrates TAL-specific Kir4.1 knockout models with advanced imaging, metabolic phenotyping, tubule perfusion, and single-nucleus RNA sequencing. Aim 1 tests the hypothesis that Kir4.1 enables basolateral potassium sensing and thereby regulates TAL sodium and potassium handling. Aim 2 tests the hypothesis that Kir4.1-expressing TAL cells undergo structural and transcriptional remodeling— including phenotypic switching, apoptosis, or proliferation—in response to extreme dietary potassium stress. These studies aim to close a key knowledge gap in segment-specific potassium sensing and may reveal new therapeutic targets for hypokalemic disorders and diuretic resistance. The candidate’s long-term objective is to lead an independent research program focused on renal epithelial transport in genetic and acquired tubulopathies. This K08 award will provide the mentored training necessary to support this transition, with structured development in electrophysiology, high-resolution imaging, and transcriptomic analysis. The training environment at Oregon Health and Science University offers strong mentorship, institutional support, and access to leading expertise in renal physiology to foster the candidate’s development as a physician-scientist.
Grant Summary
Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $167K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $167K
2031-01-31
- 1Confirm your organization is eligible for Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb: Frequently Asked Questions
Who is eligible for the Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb?
Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb provide?
Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb provides up to $167K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb deadline?
Applications for Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb?
To apply for Kir4.1-dependent mechanisms of potassium sensing and signaling in the thick ascending limb, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.