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View full policy“Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND”
NIH
About This Grant
We propose to advance a clinical program of neural stem cell therapy for spinal cord injury (SCI) to an IND submission and clinical trial. Our work to date has demonstrated that Neural Progenitor Cells (NPCs) and Neural Stem Cells (NSCs) survive grafting to the spinal cord and extend very large numbers of axons over long distances through the lesioned rodent and large animal spinal cord. Host axons also regenerate into cell grafts occupying the lesion site, and form new synaptic connections that act as neural relays across the injury to support functional improvement in both rodents and large animals. We have identified a lead candidate human NSC/NPC line for clinical translation: an H9 human embryonic stem cell (a federally approved human cell line) that is driven to a spinal cord NSC/NPC fate. We refer to these cells as H9-scNSCs. H9-scNSCs survive grafting to cervical spinal cord hemisection and contusion lesions. This promising line of work is advancing on a translational path, supported extensively by the VA’s RR&D Gordon Mansfield Spinal Cord Injury Consortium. We aim to bring this work to the point of readiness for human clinical trials in SCI. The goal of the current application is to advance this program to submission of an FDA IND, with the eventual goal of a human clinical trial of this promising approach. For the 4 year funding period, this project will support characterization of cells, assay development, IND-enabling in vivo studies, project management and the services of regulatory experts with experience in FDA submissions.
Grant Summary
“Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND” is a NIH grant providing funding that varies by award for university, nonprofit, healthcare org. Applications are due 2029-09-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $0K
2029-09-30
- 1Confirm your organization is eligible for “Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND” from NIH, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIH before the deadline.
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“Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND”: Frequently Asked Questions
Who is eligible for the “Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND”?
“Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND” is offered by NIH and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the “Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND” provide?
“Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND” provides an amount that varies by award per award from NIH. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the “Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND” deadline?
Applications for “Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND” are due 2029-09-30 (open). Because deadlines can change, verify the date with the funder, NIH, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the “Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND”?
To apply for “Neural Stem Cells for Spinal Cord Injury: Studies leading to an IND”, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIH.