3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
PROJECT SUMMARY Brain organoids hold great potential for understanding neurodevelopmental and neurodegenerative diseases. However, their utility is constrained by several factors including necrotic core formation, immaturity, and high variability. This project aims to develop a robust and reproducible in vitro method for growing brain organoids with improved structural complexity, cellular diversity, and long-term viability. Additionally, it seeks to gain biological insights into how substrate stiffness, perfusion, and neural peptides affect brain organoid growth, maturation, and function. The project will utilize 3D printing to create vascular-like networks using synthetic multidomain peptide (MDP) hydrogels within the interior of brain organoids, while also providing brain-specific mechanical and peptide signaling cues. The first aim of the project is to investigate how the stiffness of MDP hydrogels impacts the growth and function of organoids grown around the hydrogel. The second aim involves using a 3D printed hydrogel vasculature within the organoids to determine whether perfusion through this vascular network prevents necrotic core formation. The third aim focuses on incorporating neural peptide cues into the MDP hydrogels and exploring their effects on improving cellular diversity and maturation within the brain organoids. The findings from this project will guide the development of a novel method for growing brain organoids in a reproducible and physiologically relevant manner, enhancing their utility for the study of neurodevelopmental and neurodegenerative diseases. The long-term objective is to establish robust methods for growing brain organoids that more closely mimic the human brain, offering a valuable platform for therapeutic development and disease modeling. Research will be conducted at the Salk Institute for Biological Studies and under the mentorship from Dr. Fred Gage. This project will utilize a range of quantitative neuroscience technologies and offer valuable training opportunities.
Grant Summary
3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $75K for university, nonprofit, healthcare org. Applications are due 2028-10-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $75K
2028-10-31
- 1Confirm your organization is eligible for 3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids: Frequently Asked Questions
Who is eligible for the 3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids?
3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the 3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids provide?
3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids provides up to $75K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the 3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids deadline?
Applications for 3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids are due 2028-10-31 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the 3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids?
To apply for 3D Printing Hydrogel Vasculature and Bioactive Cues within Brain Organoids, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.