Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition
NIMH - National Institute of Mental Health
About This Grant
Posttraumatic stress disorder (PTSD) is a debilitating mental health condition that disproportionately affects women, particularly those from underserved populations who face higher rates of trauma exposure. PTSD is associated with trauma-related hyperarousal (TRH), which is characterized by increased psychophysiological hyperarousal, including exacerbated fear-potentiated startle, deficits in fear extinction, and increased skin conductance response to trauma reminders. Despite evidence perimenopausal women exhibit peak PTSD prevalence rates and greater symptom severity compared to younger, reproductive-aged women, the biological mechanisms underlying this increased vulnerability to the psychological consequences of hormonal variation remain unclear. The current study aims to investigate the role of the endocannabinoid system, specifically anandamide (AEA), in modulating the severity of TRH during the menopause transition in Black women. The proposed research will test the hypothesis that lower AEA concentrations over the menopause transition will be associated with decreased estradiol concentrations and increased TRH. We will employ a combination of psychological assessments, fear conditioning paradigms, and biological measures to provide a comprehensive understanding of the mechanisms driving TRH exacerbation during perimenopause. The findings from this research have the potential to inform the development of targeted interventions for trauma-exposed women during this critical period of vulnerability. In addition, the F32 fellowship under the guidance of a distinguished mentoring team will provide the applicant with essential training in clinical and translational women's health research, neuroendocrinology, psychophysiology, advanced statistical methods, and scientific communication. This training will be crucial for the applicant's career development as an independent researcher focused on investigating the impact of trauma on women's health across the lifespan, particularly in underserved populations who suffer disproportionately from the adverse health impacts of trauma exposure.
Grant Summary
Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition is a NIMH - National Institute of Mental Health grant providing up to $83K for university, nonprofit, healthcare org. Applications are due 2029-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $83K
2029-03-31
- 1Confirm your organization is eligible for Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition: Frequently Asked Questions
Who is eligible for the Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition?
Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition provide?
Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition provides up to $83K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition deadline?
Applications for Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition are due 2029-03-31 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition?
To apply for Characterizing the role of anandamide in trauma-related hyperarousal during the menopause transition, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.