Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis
NHLBI - National Heart Lung and Blood Institute
About This Grant
PROJECT SUMMARY/ABSTRACT Bile acids have been implicated as a contributor to atherosclerosis and is commonly found to be elevated in patients with metabolic disorders and cardiovascular disease (CVD). Recently, we observed extrahepatic bile acid release in high-fat/high-sucrose (HFHS) fed and LDLR KO pig models of atherosclerosis. To reveal novel targets to treat BA abnormality in patients with CVD, we aim to use the deep-sequencing technique, ribosome profiling (ribo-seq), to investigate translational control of BA synthesizing and trafficking genes in colon, kidney, liver, and muscle in HFHS-fed and LDLR KO atherogenic pig models (Aim 1). Additionally, Ribo-seq can be used to identify small open reading frames (smORFs) which encode microprotiens. These microprotiens are often overlooked and underappreciated as key players in biology and are highly enriched in mitochondria and often found to perturb metabolic processes. Thus, we aim to filter Ribo-seq data for smORFs encoding mitochondrial microproteins and determine their impacts on cellular metabolism using untargeted metabolomics/lipidomics followed by relevant stable isotope tracing to identify affected enzymes/pathways.
Grant Summary
Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis is a NHLBI - National Heart Lung and Blood Institute grant providing up to $43K for university, nonprofit, healthcare org. Applications are due 2028-09-29 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $43K
2028-09-29
- 1Confirm your organization is eligible for Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis from NHLBI - National Heart Lung and Blood Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
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Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis: Frequently Asked Questions
Who is eligible for the Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis?
Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis is offered by NHLBI - National Heart Lung and Blood Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis provide?
Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis provides up to $43K per award from NHLBI - National Heart Lung and Blood Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis deadline?
Applications for Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis are due 2028-09-29 (open). Because deadlines can change, verify the date with the funder, NHLBI - National Heart Lung and Blood Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis?
To apply for Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHLBI - National Heart Lung and Blood Institute.