(2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder
About This Grant
Project Summary: Psychoplastogens have emerged as potential treatments for psychiatric disorders, including substance use disorders. For example, recent studies have shown that low-dose ketamine may be an effective treatment for depression and opioid use disorder (OUD). Despite promising results, the use of ketamine remains limited due to its side effects and misuse potential. More recently, researchers have turned to (2R,6R)-Hydroxynorketamine (HNK), a ketamine metabolite that has exhibited therapeutic effects in preclinical models of depression and stress, but unlike ketamine, HNK lacks misuse potential and dissociative properties. Our lab recently found that HNK reduces oxycodone withdrawal symptoms and reinstatement of oxycodone conditioned place preference. To build on these exciting data and make advancements towards potential treatments for OUD, I propose to use a combination of behavioral and cell type-specific approaches to investigate the behavioral effects and cellular mechanisms of HNK in multiple OUD models. In Aim 1, I will identify brain regions and specific cell-types involved in the therapeutic response of HNK during oxycodone withdrawal. In Aim 2, I will determine the effects of HNK on extinction and reinstatement of oxycodone self-administration. To achieve these goals, I will receive advanced training in behavioral pharmacology, sophisticated animal models of SUD, cell type-specific analysis, and chemogenetics. Overall, this proposal will provide critical insights into the neural mechanisms underlying the therapeutic effects of HNK in opioid withdrawal, highlighting its potential as a novel treatment for OUD.
Grant Summary
(2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder is a NIDA - National Institute on Drug Abuse grant providing up to $49K for university, nonprofit, healthcare org. Applications are due 2028-08-14 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $49K
2028-08-14
- 1Confirm your organization is eligible for (2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder from NIDA - National Institute on Drug Abuse, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDA - National Institute on Drug Abuse before the deadline.
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(2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder: Frequently Asked Questions
Who is eligible for the (2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder?
(2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder is offered by NIDA - National Institute on Drug Abuse and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the (2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder provide?
(2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder provides up to $49K per award from NIDA - National Institute on Drug Abuse. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the (2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder deadline?
Applications for (2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder are due 2028-08-14 (open). Because deadlines can change, verify the date with the funder, NIDA - National Institute on Drug Abuse, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the (2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder?
To apply for (2R,6R)-Hydroxynorketamine as a Novel Treatment for Opioid Use Disorder, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDA - National Institute on Drug Abuse.