Dynamics of influenza A virus infection in mallards and swine
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
PROJECT SUMMARY/ABSTRACT Influenza A virus (IAV) poses a significant burden to both human and animal health. The spillover of IAV from animals to humans can furthermore result in influenza pandemics. Mallards and swine represent two important classes of species within influenza ecology. Mallards, like other wild aquatic birds, sustain IAV diversity within nature. Swine are intermediate hosts with susceptibility to both human and avian influenza viruses. Because of this susceptibility, IAV infection in swine can result in transfer of distinct IAV lineages with pandemic potential to humans. Although both swine and mallards are susceptible to IAV, the virus shows drastically different tropism in these hosts. These differences are likely to drive distinct population dynamics of IAV within each host. I hypothesize that the genetic composition of within-host viral populations will be shaped by the spatiotemporal dynamics of infection and that changes in viral population diversity over space and time will therefore show marked differences between swine and mallards. To test this hypothesis, swine and mallards will each be infected with a barcoded virus relevant to the host species: A/swine/North Carolina/A02245294/2019 (H3N2) virus (Sw/NC/19) or A/mallard/MN/10096/99 (H3N8) virus (Ma/MN/99). These viruses will carry a genetic barcode which allows tracking of many lineages within the viral population using next generation sequencing. In Aim 1, I will determine the spatial distribution and genetic composition of virus populations within swine and mallards following infection. Using the combination of extensive tissue sampling, barcoded viruses, and next generation sequencing I will be able to track IAV populations across the anatomy of the host. In Aim 2 I will determine how influenza virus populations change over time at a given anatomical site within swine and mallards. Through repeated sampling of the same anatomical site, I will be able to determine how IAV populations are shaped over time. These findings will advance understanding of IAV dynamics within distinct host species, yielding insight into the evolutionary processes that underly the emergence of IAV pandemics.
Grant Summary
Dynamics of influenza A virus infection in mallards and swine is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $50K for university, nonprofit, healthcare org. Applications are due 2029-05-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $50K
2029-05-31
- 1Confirm your organization is eligible for Dynamics of influenza A virus infection in mallards and swine from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Dynamics of influenza A virus infection in mallards and swine: Frequently Asked Questions
Who is eligible for the Dynamics of influenza A virus infection in mallards and swine?
Dynamics of influenza A virus infection in mallards and swine is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Dynamics of influenza A virus infection in mallards and swine provide?
Dynamics of influenza A virus infection in mallards and swine provides up to $50K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Dynamics of influenza A virus infection in mallards and swine deadline?
Applications for Dynamics of influenza A virus infection in mallards and swine are due 2029-05-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Dynamics of influenza A virus infection in mallards and swine?
To apply for Dynamics of influenza A virus infection in mallards and swine, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.