DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award
About This Grant
Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Development Award (TDA) supports research ranging from preclinical validation of therapeutic leads through U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product-driven. Applicants with limited amyotrophic lateral sclerosis (ALS) experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints and pathophysiology.Applications supported by this award must begin with lead compounds in hand and must already demonstrate proof-of-concept efficacy data in at least one appropriate preclinical model system of ALS, including whole-animal and cellular model systems.Distinctive Features: Mechanism-specific, predictive/cohort-selective, target engagement and pharmacodynamic biomarker development, in parallel to the main therapeutic effort, is a critical component of the FY26 ALSRP Therapeutic Development Award. If appropriate mechanism-specific biomarkers are already available or currently in development, how the existing biomarkers will improve trial design, patient selection, and efficiency or interpretation of the proposed ALS therapeutic approach must be apparent in the application. Development of biomarkers for the purposes of diagnosis, prognosis, or measurement of general disease progression without consideration of the therapeutic development process will not be supported.Therapeutic candidates which have already been granted an IND are not appropriate for this mechanism.
Grant Summary
DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award is a Defense Health Agency Contracting Activity - DHACA grant providing funding that varies by award for nonprofit, small business, university. Applications are due 2026-09-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $0K
2026-09-30
- 1Confirm your organization is eligible for DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award from Defense Health Agency Contracting Activity - DHACA, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to Defense Health Agency Contracting Activity - DHACA before the deadline.
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DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award: Frequently Asked Questions
Who is eligible for the DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award?
DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award is offered by Defense Health Agency Contracting Activity - DHACA and is generally open to nonprofit, small business, university, municipality, tribal government, healthcare org, school district. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award provide?
DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award provides an amount that varies by award per award from Defense Health Agency Contracting Activity - DHACA. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award deadline?
Applications for DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award are due 2026-09-30 (open). Because deadlines can change, verify the date with the funder, Defense Health Agency Contracting Activity - DHACA, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award?
To apply for DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from Defense Health Agency Contracting Activity - DHACA.
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