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View full policyA Holistic Approach to Study Non-Addictive Natural Products for Pain Management
About This Grant
The National Center for Complementary and Integrative Health (NCCIH) intends to publish a Notice of Funding Opportunity (NOFO) to support collaborative interdisciplinary research that advances foundational understanding of non-addictive natural products for chronic pain management through a holistic, system-oriented approach. This initiative aligns with the NIH Helping to End Addiction Long-term (HEAL) Initiative by promoting safe, non-addictive, and prevention-oriented strategies for pain relief.Chronic pain affects tens of millions of adults in the United States, contributing to disability, diminished quality of life, and significant healthcare costs. Despite widespread public use of natural products, such as botanicals, dietary supplements, and other naturally derived compounds for pain relief, scientific evidence has not kept pace with demand. Existing research often focuses on single molecular targets or isolated pathways, which fail to capture the complex, multisystem actions of these products.The scope of natural products under this NOFO includes those commonly used by the public as well as those with emerging usage or therapeutic potential. Research is expected to take a holistic approach that examines how these products influence pain through coordinated biological pathways across the multiple organ systems, such as digestive, immune, vascular, musculoskeletal, lymphatic, metabolic/adipose tissues, and nervous system. Studies should also explore dose optimization based on the principle of hormesis, where low doses may elicit beneficial or adaptive effects while higher doses could be ineffective or harmful. In addition, investigators are encouraged to identify optimal intervention timing that aligns with the dynamic phases of pain and inflammation, thereby maximizing therapeutic outcomes and supporting physiological recovery.This program emphasizes rigorous mechanistic studies that generate foundational insights to inform future translational research and guide the development of safe, evidence-based, non-addictive strategies for pain management.
Grant Summary
A Holistic Approach to Study Non-Addictive Natural Products for Pain Management is a National Institutes of Health grant providing funding that varies by award for municipality. Applications are due 2027-05-25 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $0K
2027-05-25
- 1Confirm your organization is eligible for A Holistic Approach to Study Non-Addictive Natural Products for Pain Management from National Institutes of Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to National Institutes of Health before the deadline.
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A Holistic Approach to Study Non-Addictive Natural Products for Pain Management: Frequently Asked Questions
Who is eligible for the A Holistic Approach to Study Non-Addictive Natural Products for Pain Management?
A Holistic Approach to Study Non-Addictive Natural Products for Pain Management is offered by National Institutes of Health and is generally open to municipality. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A Holistic Approach to Study Non-Addictive Natural Products for Pain Management provide?
A Holistic Approach to Study Non-Addictive Natural Products for Pain Management provides an amount that varies by award per award from National Institutes of Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A Holistic Approach to Study Non-Addictive Natural Products for Pain Management deadline?
Applications for A Holistic Approach to Study Non-Addictive Natural Products for Pain Management are due 2027-05-25 (open). Because deadlines can change, verify the date with the funder, National Institutes of Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A Holistic Approach to Study Non-Addictive Natural Products for Pain Management?
To apply for A Holistic Approach to Study Non-Addictive Natural Products for Pain Management, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from National Institutes of Health.