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View full policyNCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)
National Institutes of Health
About This Grant
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. This NOFO will provide up to 3 years support for studies to replicate the impact of the natural product on target engagement when used by humans, and assess whether there is an association between the degree of the impact on target engagement and functional or clinical outcomes in a patient population. Applications are encouraged to design studies to determine how to optimize the impact of the natural product on target engagement by optimizing the delivery of the natural product through examination of different doses or formulations. In addition, applications can be designed to combine the natural product with another treatment approach that is known to engage the same target; or study the impact of the natural product in a target population that is more responsive. Clinical trials submitted under this NOFO are expected to be hypothesis based, milestone-driven, and directly related to the research priorities and mission of NCCIH. This R33 funding mechanism is intended to accelerate the translation of emerging basic science findings about natural products into early-stage clinical testing to determine whether continued clinical research is warranted. This NOFO will not support efficacy or effectiveness trials, nor will
Grant Summary
NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) is a National Institutes of Health grant providing up to $1.1M for municipality. Applications are due 2026-11-13 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $1.1M
2026-11-13
- 1Confirm your organization is eligible for NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) from National Institutes of Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to National Institutes of Health before the deadline.
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NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required): Frequently Asked Questions
Who is eligible for the NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)?
NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) is offered by National Institutes of Health and is generally open to municipality. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) provide?
NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) provides up to $1.1M per award from National Institutes of Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) deadline?
Applications for NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required) are due 2026-11-13 (open). Because deadlines can change, verify the date with the funder, National Institutes of Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)?
To apply for NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required), confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from National Institutes of Health.