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U.S. National Science Foundation

Safety, Security, and Privacy of Open-Source Ecosystems

Salesforce.org

Supports nonprofits and social enterprises with technology grants, product donations, and capacity building through the Salesforce ecosystem.

NIAID - National Institute of Allergy and Infectious Diseases

Project Summary Host-adapted Salmonella enterica strains cause systemic infections and can persist in granulomas within host tissues for extended periods. Often asymptomatic, persistently infected hosts act as crucial reservoirs, silently transmitting the pathogen to new hosts. From a bacterial perspective, maintaining a persistent state is vital for survival in natural settings. Despite this importance, the molecular mechanisms governing Salmonella persistence and host-to-host transmission remain elusive. A clearer understanding of these processes could pave the way for pharmacological eradication of the Salmonella carrier state. Our overarching goal is to unravel how Salmonella enterica serovar Typhimurium (STm) maintains persistence in mammalian tissues, aiming to identify host pathways for preventive and therapeutic innovations. This proposal’s objective is to uncover how STm achieves persistence in mammalian tissues, with the aim of identifying host pathways amenable to preventive and therapeutic strategies. Specifically, we will examine granuloma dynamics and STm survival mechanisms in mesenteric lymph nodes (MLN). The primary objective of this research is to comprehensively characterize dynamics of STm colonization of MLN and to elucidate eosinophil functions that impact pathogen persistence. This will be investigated by examining the interactions between eosinophils and STm, both in vitro and in vivo (Aim 1), and exploring immune-pathogen interactions within distinct MLNs through spatial transcriptomics and immune profiling (Aim 2). Additionally, we aim to characterize the immunoregulatory functions of eosinophils that influence STm persistence in MLNs (Aim 3). Through these efforts, we aim to reveal critical insights into the interplay between host immune pathways and persistent Salmonella infections, informing future strategies to combat chronic bacterial carriage.

Scappoose Public Library District

The Scappoose Public Library will migrate to the integrating library system (ILS) that is currently in use by the St. Helens Public Library. This will enhance both libraries' infrastructure by providing a joint ILS that is cloud hosted, web based, and compatible with mobile devices. It will also enhance St. Helens patrons' discovery of ebooks as the new catalog will have the ability to check out ebooks directly. This merger coud serve as an intial building block for future union catalogs among other libraries in Columbia County.

U.S. National Science Foundation

Scholarships in STEM Network

Swiss Agency for Development and Cooperation (SDC)

Co-funds research partnerships between Swiss and developing-country institutions addressing global challenges including ecosystems, food security, employment, and governance.

Langston Hughes Performing Arts Institute

On September 21st and 22nd, LANGSTON will produce the first annual Seattle Black Nerd Fest: a free 2-day convention centering Black and brown community members interested in Afrofuturism, comic books, video games, STEM (Science, Tech, Engineering, Math), science fiction, fantasy, and more. Seattle Black Nerd Fest will center BIPOC voices within the nerd space - and provide an opportunity for BIPOC nerds, of all ages, to gather, meet creators, experts, and each other. Our convention will feature workshops, film screenings, panel discussions, meet and greets, mentoring sessions, vendors, interactive exhibits, and more.

Accurate Control Inc

Building and Facility Construction and Maintenance Services

Somers

Security System Upgrade - School

Groton

Senior Center Closed Circuit TV System for Public Area Monitoring

Employment and Training Administration (ETA)

SCSEP is a community service and work-based training program for older workers authorized in Title V of the Older Americans Act (OAA) and administered by USDOL/ETA. SCSEP is the only federally sponsored employment and training program targeted specifically to low-income older individuals. SCSEP provides subsidized, part-time, community service training for unemployed, low-income persons aged 55 or older who have poor employment prospects. Through this program, older workers have access to SCSEP services and employment training assistance through the One-Stop Career Center System. Program participants work an average of 20 hours a week and are paid the highest of the federal, state, or local minimum wage. Service priority is given to individuals meeting one or more of the following criteria: Is a veteran or a spouse of a veteran; Is 65 years of age or older; Has a disability; Has limited English proficiency; Has low literacy skills; Resides in a rural area; Has low employment prospects; Has failed to find employment after utilizing services provided under Title I of WIOA; Is homeless or at risk for homelessness; or Are formerly incarcerated or on supervision from release from prison or jail within five years of the date of initial eligibility determination. (Effective March 25, 2021, the 2020 reauthorization of the Older Americans Act (OAA) added this tenth characteristic category that has priority of service over those individuals who meet only the basic eligibility criteria related to age, income, and employment.)

NIAID - National Institute of Allergy and Infectious Diseases

SUMMARY RNA viruses pose a threat to organisms ranging from bacteria to humans, and thus all hosts need to recognize and defend themselves from these foreign invaders. While some principles of RNA virus recognition have been defined, primarily in mammalian systems, there remains a significant gap in knowledge as to how different hosts recognize the presence of an RNA virus. Much less is known about how simple metazoans, such as the model organism C. elegans, recognize virus infection. Studies in C. elegans have led to the discovery of multiple fundamental paradigms in biology, such as identification of caspase cell death pathways and RNA interference (RNAi). The discovery over a decade ago of Orsay virus (ORV), a positive strand RNA virus that is the first and only known natural virus of C. elegans to date, opened the door to virus-host interaction studies in this simple, multicellular invertebrate model system. Defining the host genes required for recognizing an RNA virus and the viral derived molecules that are sensed by C. elegans will provide novel insights into the evolution of self-versus-nonself discrimination. These studies could also lead to identification of novel viral recognition and signaling pathways that are broadly conserved. In mammals a family of cytoplasmic receptors that includes RIG- I and MDA5 senses the presence of intracellular RNA virus derived products. They then signal through additional proteins, such as MAVS, to activate transcription factors, including IRF3, IRF7, and NF-kB to induce an antiviral transcriptional response. C. elegans encodes DRH-1, a dicer related helicase that is homologous to RIG-I and MDA5, that is required for activation of the C. elegans transcriptional response, termed the intracellular pathogen response (IPR), to ORV infection. However, since C. elegans does not possess orthologs of MAVS, IRF3, IRF7 or NF-kB, it is not clear how the sensing of an RNA virus is transduced in C. elegans and what genes are involved. The viral derived molecule(s) that are recognized in C. elegans is also poorly defined. RIG-I binds viral dsRNA with a 5' triphosphate while MDA5 binds longer dsRNAs independent of the 5' terminus. In C. elegans, replication of ORV from a plasmid-based replicon system is sufficient to activate the IPR implicating an ORV replication product as the trigger. In preliminary data, we demonstrated that non-replicating ORV dsRNA produced by the endogenous C. elegans transcription machinery is sufficient to activate the IPR in vivo. This implies that viral dsRNA with 5' cap structure can be a trigger, providing the first evidence that DRH-1 maybe more similar to MDA5 than RIG-1. Thus, studies of DRH-1 may provide novel insights into the evolution and function of MDA5-like sensing proteins. Here, we will (1) define the host factors that recognize viral infection and are responsible for transducing that signal into a transcriptional response, and (2) determine the precise nature and characteristics of the viral ligand(s) that is recognized by C. elegans.

Friends of Seward Park

Western Hemlocks are dying in the northwest quadrant of the Seward Park's old-growth forest located at 5895 Lake Washington Blvd. The cause and mechanism of the decline are unknown. A survey of current tree health and geographic distribution is needed. The Friends of Seward Park will work with youth from CHOOSE 180 on a hemlock survey, collecting data and training the youth in field biology and data analysis. A protocol devised by PNW ecologists and pathologists and approved by Seattle Parks will guide our work. CHOOSE 180 is a community-centered program in partnership with the King County Prosecuting Attorney's Office to reduce race-based and economic disproportionality in the juvenile justice system. Friends of Seward Park will also collaborate with Forest Health Watch, provide data summaries, a preliminary analysis, and a short article submitted to an appropriate journal. This project will be completed by November 30, 2021.

City of Weston

Sewer Collection System Evaluation

City of Elgin

Sewer System Improvements

City of Vernonia

Sewer System Improvements - Construction

City of Saint Helens

Sewer System Improvements - Design

Greenwich

Sewer System Rehab

Greenwich

Sewer System Rehabilitation

City of Vernonia

Sewer System Repairs and Improvements

Town of Delmar

Sewer System Study

City of Toledo

SF Mainline Replacement & Collection System Improv

Groton

Shennecossett Golf Course HVAC System Upgrade

Shield Crest Water Company

Shield Crest WaterCo WaterSystem Feasibility Study